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🔥 Good Morning from Top Tickers

A Cancer Drug Just Moved a Stock 37%

Premarket is splitting cleanly along a single fault line today: the stocks with genuine, company-specific catalysts are moving on their own logic, and the stocks caught in the macro crossfire are getting swept up in something they can't control.

A blockade announcement pushed oil back above $103, and that one development is cascading across cruise lines, airlines, and energy names simultaneously. Elsewhere, a clinical trial result and a $2.5 billion acquisition are doing the heavy lifting on the gainers side.

The standout story of the morning is a biotech whose drug data landed so clean that the market didn't need to debate it. Everything else is about who absorbs the macro noise and who benefits from it.

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🚀 Pre-Market Movers

The Biggest Gainers, Ranked

Revolution Medicines (RVMD): +37%

A phase 3 trial just handed Revolution Medicines one of the most compelling oncology readouts in recent memory. Its daily pill daraxonrasib nearly doubled survival time for pancreatic cancer patients versus chemotherapy, and in a disease with almost no good options, that kind of data is the whole story.

Leggett & Platt (LEG): +9%

The struggling manufacturer found a buyer. Somnigroup International (SGI), the bedding giant behind Tempur-Pedic and Sealy, agreed to acquire Leggett & Platt in a $2.5 billion all-stock deal expected to close by year-end. For a company that has faced persistent pressure on its business model, an exit at a premium is a welcome resolution.

Palantir (PLTR): +2%

After getting hit for more than 13% last week, its worst stretch since April 2025, Palantir is bouncing. The sell-off was driven by concerns that AI could disrupt the very software companies that benefit from it. The rebound looks more like stabilization than conviction. President Donald Trump also praised Palantir in a post to Truth Social on Friday, so market watchers think that may also be helping with sentiment.

Williams-Sonoma (WSM): +2%

Goldman Sachs upgraded the kitchen and cookware retailer to buy, calling its valuation attractive and its brand portfolio one of the strongest in all of retail. In an environment where consumer discretionary names are under pressure, a vote of confidence from a major bank carries weight.

Targa Resources (TRGP): +1%

Oil prices crossing back above $103 following the U.S. Navy's announced blockade on the Strait of Hormuz lifted energy names broadly. Targa, a midstream infrastructure operator, is the top gainer in the group today.

📉 Pre-Market Movers

The Biggest Losers, Ranked

Fastenal (FAST): -4%

Fastenal met the Street's expectations on earnings and revenue and is getting punished for it. In this tape, matching consensus isn't enough, and a company in industrial distribution with no upside surprise to offer gets sold.

Best Buy (BBY): -4%

Goldman Sachs downgraded the electronics retailer to sell, warning that a short-term boost from PC demand pull-forward won't last. Once rising memory costs start flowing through to laptop and computer prices, the tailwind reverses and becomes a headwind.

Goldman Sachs (GS): -2%

Speaking of Goldman, the bank beat on earnings and revenue, with record equities trading driving the headline. But fixed income and currencies trading came in well short of expectations, and that miss is what the market is focused on. When the good news is priced in and the miss is not, the stock falls even on a beat.

Carnival (CCL): -4%

Rising energy prices are hitting cruise operators from two directions at once: higher fuel costs and growing fears about consumer demand. Carnival is the largest name in the group and is absorbing the biggest move lower.

United Airlines (UAL): -2.5%

Surging jet fuel costs tied to the Strait of Hormuz situation and demand anxiety are weighing on airline stocks. United is the lead mover in the group today.

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👀 What We’re Watching

Here’s One Ticker That’s Trending Today

Aeluma (ALMU)

Aeluma is trending on StockTwits as investors debate its upside in silicon photonics versus the real execution risk of scaling from early-stage government contracts into full commercial manufacturing. Sentiment is split: bulls see its proprietary 300mm wafer technology as a high-upside opportunity, while skeptics point to limited current revenue and ongoing share issuance as reasons for caution.

Freedom Capital upgraded the stock to strong buy on April 2, and Benchmark and UBS both carry buy ratings with a $25 price target. But the stock is currently trading well below that target and sitting under its 50-day moving average after a sharp pullback from its 52-week high. Whether the technology story is enough to bridge the gap between where the company is and where believers think it's going is exactly what the community is debating.

✌️That’s it for today.

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